"a way out," "way of escape," 1 Corinthians 10:13 (ek, "out," baino, "to go"), is rendered "issue" in Hebrews 13:7 , RV, for AV, "end," regarding the manner of life of deceased spiritual guides. See END.
"a flowing" (akin to rheo, "to flow"), "an issue," is used in Mark 5:25; Luke 8:43,44 .
Note: In Matthew 22:25 , AV, sperma, "seed," is translated "issue" (RV, "seed")."to cause to go forth" (ek, "out," poreuo, "to cause to go"), is used in the Middle Voice in Revelation 9:17,18 , of the coming forth of fire, smoke and brimstone from the mouths of the symbolic horses in a vision, AV, "issued" (the RV renders it by the verb "to proceed"). See COME , DEPART , GO , PROCEED.