Ephe'sians, The Epistle to The. The Epistle to the Ephesians was written by the apostle St. Paul, during his first captivity at Rome, Acts 28:16, apparently immediately after he had written the Epistle to The Colossians, see Colossians, The Epistle to the, and during that period, (perhaps the early part of A.D. 62), when his imprisonment had not assumed the severer character which seems to have marked its close. This Epistle was addressed to the Christian church at Ephesus. See Ephesus. Its contents may be divided into two portions, the first mainly doctrinal, Ephesians 1-3, the second hortatory and practical.