C21H21N06j an alkaloid found with berberine in the root of golden seal, Hydrastis canadensis, a plant indigenous to North America. It was discovered by Durand in 1851, and its chemistry formed the subject of numerous communications by E. Schmidt and M. Freund (see Ann., 1892, 271, p. 311) who, aided by P. Fritsch (Ann., 1895, 286, p. 1), established its constitution. It is related to narcotine, which is methoxy hydrastine. The root of golden seal is used in medicine under the name hydrastis rhizome, as a stomachic and nervine stimulant.