Second Duke of, and son of preceding; rose, to the highest eminence as a soldier, winning, besides many others, the great victory of Metz over the Germans, and capturing Calais from the English in 1558; along with his brother Charles (q. v .) he was virtual ruler of France during the feeble rule of Francis II., and these two set themselves to crush the rise of Protestantism; he was murdered by a Huguenot at the siege of Orleans (1519-1563).