Rabbi of Salonica in the sixteenth century; uncle of Jacob b. Solomon Matalon. Besides being a prominent Talmudist, Matalon was, according to his companion Samuel di Modena, who quotes him frequently in his responsa, well versed in secular sciences (Responsa on Ḥoshen Mishpaṭ, No. 40). He is quoted also by Isaac Adarbi in his "Dibre Ribot" (Nos. 217, 326). Matalon was the author of responsa inserted in the "Mishpeṭe Shemuel." of Samuel Ḳala'i (Venice, 1599).