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Bridgeway Bible Dictionary
Over the centuries leading up to the New Testament era, the numerous independent states of Asia Minor had been brought under the control of firstly the Greeks, then the Romans. In the New Testament period a number of them were joined together to form what became known as the province of Asia. The local people, however, continued to use the names of the former states when referring to certain regions.
In the north-west of the newly formed province was the former region of Mysia, which included the towns of Troas, Assos, Adramyttium and Pergamum. In the south-east was part of the former region of Phrygia, the other part of which was in the neighbouring province of Galatia. The towns of Colossae, Laodicea and Hierapolis fell within the part of Phrygia that was in the province of Asia.
Phrygia was the region where Paul first entered the province of Asia (during his second missionary journey), but God did not allow him to preach there. Paul therefore headed north towards the province of Bithynia, but he was forbidden to preach there also. He then headed west across Mysia to Troas, from where he sailed for Europe (Acts 16:6-11).
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Fleming, Don. Entry for 'Asia'. Bridgeway Bible Dictionary. https://www.studylight.org/dictionaries/eng/bbd/a/asia.html. 2004.