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1911 Encyclopedia Britannica
a substance formed by the action of sodium glycol on ethylene-diamine hydrochloride, consisting of small alkaline deliquescent crystals with a saline taste and soluble in water. It was originally introduced into medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body piperazin has a remarkable power of dissolving uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Lycetol, lysidine and sidonal are bodies having similar action.
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Chisholm, Hugh, General Editor. Entry for 'Piperazin'. 1911 Encyclopedia Britanica. https://www.studylight.org/encyclopedias/eng/bri/p/piperazin.html. 1910.