International Standard Bible Encyclopedia
Such an affection of the knees may be due to different causes. It is, e.g., a very frequent symptom of the disease known in the Orient as
The "sore boil ... in the knees, and in the legs," a disease announced in Deuteronomy 28:35 as a punishment upon Israel for disobedience, cannot now be fully determined. Driver (in his commentary on the passage) thinks of elephantiasis, which is possible but not probable on account of the additional statement, "whereof thou canst not be healed, from the sole of thy foot unto the crown of thy head" which would be unexplained, as elephantiasis rarely presents a form in which the whole body is sympathetically affected. I rather think of some form of bubonic plague, which causes very high fever all over the body. In Deuteronomy 28:27 in the enumeration of plagues mention is made of the "boil of Egypt," and some commentators have explained this as "bubonic plague." There is, however, no doubt that the "boil or botch of Egypt" is identical with the disease known to modern medicine as bouton du Nil , Biskra button, Bagdad or Aleppo sore.
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Orr, James, M.A., D.D. General Editor. Entry for 'Feeble Knees'. International Standard Bible Encyclopedia. https://www.studylight.org/encyclopedias/eng/isb/f/feeble-knees.html. 1915.