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Kitto's Popular Cyclopedia of Biblial Literature
A city on the banks of the Orontes, 300 miles north of Jerusalem, and about 30 from the Mediterranean. It was situated in the province of Seleucis, called Tetrapolis. It was the metropolis of Syria, the residence of the Syrian kings, and afterwards became the capital of the Roman provinces in Asia. It ranked third, after Rome and Alexandria, among the cities of the empire, and was little inferior in size and splendor to the latter. Its suburb Daphne was celebrated for its grove and fountains, its asylum and temple were dedicated to Apollo and Diana. It was very populous; within 150 years after its erection the Jews slew 100,000 persons in it in one day. In the time of Chrysostom the population was computed at 200,000, of whom one-half, or even a greater proportion, were professors of Christianity. Cicero speaks of the city as distinguished by men of learning and the cultivation of the arts. A multitude of Jews resided in it. Seleucus Nicator granted them the rights of citizenship, and placed them on a perfect equality with the other inhabitants. These privileges were continued to them by Vespasian and Titus. Antioch is called libera by Pliny, having obtained from Pompey the privilege of being governed by its own laws.
Kitto, John, ed. Entry for 'Antioch'. "Kitto's Popular Cyclopedia of Biblial Literature". https://www.studylight.org/encyclopedias/eng/kbe/a/antioch.html.